FIGURE

Fig. 1

ID

ZDB-FIG-140107-53

Publication

Borovina et al., 2013 - IFT88 Plays a Cilia- and PCP-Independent Role in Controlling Oriented Cell Divisions during Vertebrate Embryonic Development

Other Figures

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Fig. 1

MZift88 Mutants Do Not Form Cilia

(A and B) Lateral view of a 3-day-old (A) Mift88 embryo and (B) MZift88 mutant embryo exhibiting a curved body axis, pericardial edema (arrowhead), hydrocephalus (asterisk), and a cystic kidney (arrow).

(C and D) Confocal images of (C) WT and (D) MZift88 mesoderm cells, at 9 hpf, expressing Arl13b-GFP (green) and memb-mRFP (red) revealed the presence of cilia on WT cells (asterisks, C). Only small puncta of Arl13b-GFP were visible on MZift88 mutant cells (asterisks, D).

(E) Transmission electron microscopy micrograph of basal body docking in the neural tube of a 30hpf MZift88 mutant embryo.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ift88^tz288/tz288
Observed In:	brain mesoderm cilium neural tube neural tube axoneme pericardium pronephros whole organism
Stage Range:	90%-epiboly to Protruding-mouth

Phenotype Detail

Acknowledgments

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