FIGURE

Fig. 6

ID

ZDB-FIG-131108-7

Publication

Zaucker et al., 2013 - notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Distension of vessels in notch3 mutants. (A) Schematic depicting cross-section and the ordered arrangement of arteries within the bony regions and larger caliber veins within the joints of the fin rays observed in (B) wild type, (C) notch3^st51/+ and (E) notch3^zm/+ heterozygotes. This pattern is moderately disrupted in (D) notch3^st51/st51 mutants and severely disrupted in (F) notch3^zm/zm mutants. (B–F) Toluidine-blue-stained sections. Scale bars: 50 μm. A, artery; A?, probable artery based on position; V, vein; hv, hemorrhaged vessel. (G) Schematic depicting the strategy for quantification of vessel defects (detailed in the Materials and Methods). (H) Box plot of results reveals significantly larger vessels within the bony segments of the fin of notch3 mutants compared with wild-type adults. ANOVA results: mean squares between=6.7821×10²; mean squares error=3.4565×10³; P<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	notch3^st51/st51
Observed In:	caudal fin blood vessel
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.