FIGURE

Fig. 5

ID

ZDB-FIG-131108-6

Publication

Zaucker et al., 2013 - notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish

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Fig. 5

Vessels are more prominent in the telencephalon of notch3 mutants compared with wild type. (A–F) Overview images of dissected adult brains. (G–J) High-magnification images of the telencephalon. Compared with (A,B,G) wild-type and (C,D,I) heterozygous genotypes, vessels are more prominent in the telencephalon of (E,H) notch3^zm/zm and (F,J) notch3^st51/st51 mutants. (G–J) Large vessels and accumulation of blood (arrows) are apparent in mutant telencephalons. (K–N) H&E-stained sections of the medial telencephalon of (K) notch3^zm/+, (L) notch3^zm/zm, (M) notch3^st51/+ and (N) notch3^st51/st51 mutants. Small vessels traverse the tissue in heterozygotes, whereas large dilated vessels are present in homozygous mutant telencephalon. Blue arrows denote vessels. tel, telencephalon; tec, tectum; cer, cerebellum. The orientation of the anterior (A) and posterior (P) axis is indicated. (K–N) Scale bars: 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	notch3^st51/st51 notch3^{zm197263Tg/zm197263Tg}
Observed In:	optic tectum blood vessel optic tectum capillary telencephalon blood vessel
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.