FIGURE

Fig. 4

ID

ZDB-FIG-130909-13

Publication

Kim et al., 2013 - Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

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Fig. 4

AKT activity in p53^zdf1/zdf1 and tsc2;p53 compound mutant tumors. (A–F) Phospho-tuberin (p-Tsc2) staining in p53^zdf1/zdf1 and tsc2;p53 compound mutant zebrafish. (B,C and E,F) Higher magnification of A and D, respectively. (C,F) Phospho-tuberin (Ser939, red); (B,E) phospho-tuberin (red) merged with DAPI (blue). (G,J) Total Akt immunofluorescence, (H,K) phospho-Akt (Thr308) immunofluorescence and (I,L) phospho-Akt (Ser473) immunofluorescence in p53^zdf1/zdf1 (G–I) and tsc2;p53 compound mutant (J–L) zebrafish. M, muscle; T, tumor. Scale bars: 100 μm.

Expression Data

Antibodies:	Ab2-akt Ab3-tsc2 Ab7-akt
Fish:	tp53^zdf1/zdf1 tp53^zdf1/zdf1; tsc2^vu242/+
Anatomical Terms:	eye sarcoma trunk sarcoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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