FIGURE

Fig. 2

ID

ZDB-FIG-130907-27

Publication

McCarthy et al., 2013 - Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD

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Fig. 2

Ethanol induces pharyngeal hypoplasia in pdgfra mutants. (A-C) Flat-mounted jaw and jaw support elements, anterior towards the left. Untreated (A) wild-type, (B) pdgfra^+/- and (C) pdgfra^-/- embryos have normally shaped cartilages. (D,E) Treatment with 1.0% ethanol from 10 hpf to 5 dpf does not affect the overall shape of cartilages in (D) wild-type or (E) pdgfra heterozygous embryos. (F) Ethanol treatment greatly disrupts the shape of the palatoquadrate and hyosymplectic cartilages in pdgfra mutants. (G-I) Quantification of the average area, in thousands of μm² of (G) Meckel’s (mc), (H) palatoquadrate (pq) and (I) hyosymplectic (hs) cartilages (standard error bars are depicted at 1.5 s.e.m., significance is indicated by non-overlapping bars; Moses, 1987). Wild type, light bar; pdgfra heterozygote, light-gray bar; pdgfra mutants, dark-gray bar. ch, ceratohyal. Group numbers are the same as for Fig. 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdgfra^b1059/b1059 pdgfra^b1059/+
Condition:	chemical treatment: ethanol
Observed In:	hyosymplectic cartilage Meckel's cartilage palatoquadrate cartilage
Stage:	Day 5

Phenotype Detail

Acknowledgments

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