FIGURE

Fig. 2

ID

ZDB-FIG-130826-55

Publication

Pascoal et al., 2013 - Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish

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Fig. 2

Abnormal pectoral fins are formed in Notch signalling disrupted larvae.

(A-F) Live pictures of 5 dpf larvae. (A′) A pectoral fin from a sibling embryo showing the cartilaginous endoskeletal disc with individualized cells surrounded by thin matrix deposits, the fin fold and the chleitrum (n = 17) (E, E′). A similar pectoral fin was found in a DMSO-treated embryo (n = 9). Pectoral fins of Notch signalling disrupted embryos such as mib^ta52b (n = 18) (B, B′), jagged2 (n = 10) (C, C′) and Su(H)1+2 (n = 12) (D, D′) morphants and DAPT-treated embryos (n = 10) (F, F′) showing disorganized endoskeletal disc cells. cl, chleitrum; ed, endoskeletal disc; ff, fin fold.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^ta52b/ta52b WT + MO1-jag2b WT + MO5-rbpja,rbpjb
Knockdown Reagents:	MO1-jag2b MO5-rbpja,rbpjb
Observed In:	pectoral fin endoskeletal disc pectoral fin fold
Stage:	Day 5

Phenotype Detail

Acknowledgments

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