FIGURE

Fig. S6

ID

ZDB-FIG-130725-8

Publication

Helker et al., 2013 - The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment

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Fig. S6

Vegfc positively regulates EC proliferation in the CCVs. Confocal projections of 32 hpf Tg(kdrl:EGFP)^s843 wild-type siblings (A), homozygous vegfc^hu6410 mutant embryos (B) or embryos injected with H2B-cherry mRNA (control, C), vegfc mRNA (D) or sFLT4 mRNA (E), all pulsed with BrdU from 24-32 hpf. BrdU staining is shown in red; vascular ECs are visualized in green by staining for GFP expression [of Tg(fli1al:EGFP)^y1 in A,B and of Tg(kdrl:EGFP)^s843 in C-E]. EC proliferation is decreased in vegfc^hu6410 (B) or sFLT4 mRNA-injected (E) embryos and increased upon vegfc overexpression (D). Arrowheads mark BrdU-positive ECs in the CCV.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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