FIGURE

Fig. 6

ID

ZDB-FIG-130508-1

Publication

Choudhry et al., 2013 - DiGeorge Syndrome Gene tbx1 Functions through wnt11r to Regulate Heart Looping and Differentiation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

wnt11r and tbx1 cooperate to regulate heart looping and differentiation.

(A-C) ISH showing wnt11r expression in the fusing heart fields (21 somites, A), linear heart tube (24 hpf, B) and fully looped heart (48 hpf, C) in WT embryos. (D, E) Dissected hearts from WT (D) versus tbx1^-/- mutant (E) embryos stained for wnt11r expression at 48 hpf. The heart boundaries are indicated by dotted lines. Arrows point to the AVC. Scale bars: 50 µm. (F, G) Quantification of penetrance of looping and regional differentiation defects in double heterozygotes as compared to single heterozygotes of tbx1 and wnt11r. WT is shown as negative control, and tbx1^-/- and wnt11r^-/- mutants as positive control for looping and regional differentiation defects. N depicts the total number of embryos from 3 experiments.

Expression Data

Gene:	wnt11
Fish:	WT tbx1^tm208/tm208
Anatomical Terms:	heart heart primordium heart tube
Stage Range:	20-25 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx1^tm208/+; wnt11^fh224/+
Observed In:	heart looping
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One