FIGURE

Fig. 2

ID

ZDB-FIG-130429-56

Publication

Choudhry et al., 2013 - DiGeorge Syndrome Gene tbx1 Functions through wnt11r to Regulate Heart Looping and Differentiation

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Fig. 2

Cell shape defects in tbx1^-/- mutants.

(A, B) Confocal projections of hearts from Tg(cmlc2:EGFP) embryos at 48 hpf stained with Alcama antibody (red) to demarcate cell boundaries. Cells in the outer and inner chambers are outlined in white and yellow respectively. The insets in E and F show a magnified view of the outer curvature cell outlined in white. The plot in C shows that cells in the outer chamber of tbx1^-/- mutants are rounder (circularity tending towards 1) as compared to WT. (D) Cell shape is unchanged in the inner chamber of tbx1^-/- mutants. Each bar in plots C and D represents data collected from 70 cells in 7 different embryos. Arrows point to the AVC; v, ventricle; a, atrium. Scale bars: 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx1^tm208/tm208
Observed In:	cardiac muscle cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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