FIGURE

Fig. 6

ID

ZDB-FIG-130208-22

Publication

Monk et al., 2013 - Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology

Other Figures

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Fig. 6

sec63^st67 mutants develop numerous liver pathologies. (A–F) TEM images showing liver ultrastructure at 8 dpf in wild-type and sec63^st67 mutant zebrafish. (A) Wild-type liver; arrow points to ER with normal morphology. (B) sec63^st67 mutant liver; ER is swollen (arrows) and cytoplasm is disrupted. (C,D) Ultrastructure of bile canaliculi (*) in wild-type (C) and sec63^st67 mutant (D) livers. sec63^st67 bile canaliculi appear disorganized compared with the wild type. Lysosomes are filled with debris in sec63^st67 mutants (F; arrows) but not in the wild type (E). Scale bars: 500 nm (A–D); 2 μm (E,F).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sec63^st67/st67
Observed In:	liver bile canaliculus liver endoplasmic reticulum liver endoplasmic reticulum lumen liver mitochondrial crista liver mitochondrion
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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