ZFIN Image: Monk et al., 2013, Fig. 6

Image

Figure Caption

Fig. 6 sec63^st67 mutants develop numerous liver pathologies. (A–F) TEM images showing liver ultrastructure at 8 dpf in wild-type and sec63^st67 mutant zebrafish. (A) Wild-type liver; arrow points to ER with normal morphology. (B) sec63^st67 mutant liver; ER is swollen (arrows) and cytoplasm is disrupted. (C,D) Ultrastructure of bile canaliculi (*) in wild-type (C) and sec63^st67 mutant (D) livers. sec63^st67 bile canaliculi appear disorganized compared with the wild type. Lysosomes are filled with debris in sec63^st67 mutants (F; arrows) but not in the wild type (E). Scale bars: 500 nm (A–D); 2 μm (E,F).

Figure Data

Phenotype details

Acknowledgments

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