FIGURE

Fig. 7

ID

ZDB-FIG-121203-13

Publication

Chen et al., 2012 - MANF regulates dopaminergic neuron development in larval zebrafish

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Fig. 7

Increase of nr4a2b and pax2a expression in manf MOsp morphants at 3 dpf. The spatial distribution of nr4a2b and pax2a was revealed by whole mount in situ hybridization. (A–C) dorsal views of nr4a2b expression pattern in the head and (D–F) lateral views of the spinal cord. (G–H) dorsal views of pax2a expression pattern in the head and (J–L) lateral views of the spinal cord. qPCR analysis of nr4a2b (M), pax2a (N) and pax5(O) (*p<0.05, n=3, Student′s t-test). White rectangles indicate the increase of nr4a2b expression in the posterior tuberculum and white arrows indicate the increased nr4a2b and pax2a expression in rhombencephalon in manf MOsp morphants. Scale bar=100 μm.

Expression Data

Genes:	nr4a2b pax2a
Fish:	WT WT + MO2-manf + MO3-manf
Knockdown Reagents:	MO2-manf MO3-manf
Anatomical Terms:	brain nucleus caudal tuberculum hindbrain midbrain hindbrain boundary spinal cord
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-manf + MO3-manf
Knockdown Reagents:	MO2-manf MO3-manf
Observed In:	dopaminergic neuron differentiation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 370(2), Chen, Y.C., Sundvik, M., Rozov, S., Priyadarshini, M., and Panula, P., MANF regulates dopaminergic neuron development in larval zebrafish, 237-249, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.