FIGURE

Fig. 2

ID

ZDB-FIG-121102-19

Publication

Cui et al., 2012 - Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

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Fig. 2

SU5416 protects against MPTP-induced TH+ region area decrease in zebrafish.

One dpf zebrafish embryos were co-incubated with 200 μM MPTP and SU5416, VRI or 0.3% DMSO (vehicle control) at the indicated concentrations for 2 days. After treatment, zebrafish were collected to perform whole-mount immunohistochemistry. (A) Representative pictures of whole-mount immunostaining of zebrafish brain from different treatment groups. (B) Magnification of diencephalic area of zebrafish larval (indicated by red bracket in Fig. 2A). (C) Statistical analysis of TH⁺ region area in each treatment group (20 fish embryos per group). Data, expressed as percentage of control, were the mean ± SEM of three separate experiments; ^##p<0.01 versus control; *p<0.05 and **p<0.01 versus MPTP group (Turkey’s test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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