FIGURE

Fig. 6

ID

ZDB-FIG-121101-15

Publication

Weiss et al., 2012 - Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos

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Fig. 6

Ocular vessel dilation is flow dependent and interferes with optic fissure closure. (A–D) Single plane confocal images combined with transmitted light image of eyes of normal Tg(kdrl:EGFP) embryos (A and C) and lmo2^vu270/vu270; Tg(kdrl:EGFP) embryos (B,D), uninjected (A and B) or injected with MO1-tnnt2a (C and D). Arrows point at GFP-positive endothelial cells (green) in close contact with optic fissure margins. (A′–D′) Images of the same embryos as in A–D. Arrows point at optic fissure margins. Embryos were treated with PTU to block pigmentation. All panels are lateral view, anterior to the left.

Expression Data

Gene:	EGFP
Fish:	s843Tg s843Tg + MO1-tnnt2a lmo2^vu270/vu270; s843Tg lmo2^vu270/vu270; s843Tg + MO1-tnnt2a
Knockdown Reagent:	MO1-tnnt2a
Anatomical Term:	ocular blood vessel blood vessel endothelium
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lmo2^vu270/vu270; s843Tg lmo2^vu270/vu270; s843Tg + MO1-tnnt2a
Knockdown Reagent:	MO1-tnnt2a
Observed In:	blood circulation embryonic hemopoiesis embryonic retina morphogenesis in camera-type eye head heart contraction nucleate erythrocyte ocular blood vessel optic fissure
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 369(2), Weiss, O., Kaufman, R., Michaeli, N., and Inbal, A., Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos, 191-198, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.