FIGURE

Fig. 5

ID

ZDB-FIG-121101-14

Publication

Weiss et al., 2012 - Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos

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Fig. 5

Dilated vessels are located in the optic fissure. (A–F) Three-dimensional shadow rendering of confocal z-stacks of eyes (green) and ocular vessels (red) in 2 dpf (rx3:Gal4-VP16);(UAS:EGFP);(kdrl:HsHRAS-mCherry) transgenic normal (A–C) and lmo2^vu270/vu270 (D–F) embryos. In the merged panels (C and F) most of the hyaloid vessels cannot be seen. (E and F) Growth of superficial ring vessel is delayed in the mutant (compare to B and C). Arrows point at the optic fissure. Inset in F is a higher magnification of the optic fissure area with the arrow pointing at the dilated vessel in the fissure. Vessel abbreviations are as in Fig. 2. All panels are dorsolateral view, anterior to the left.

Expression Data

Genes:	EGFP mCherry
Fish:	s896Tg; vu157Tg; vu271Tg lmo2^vu270/vu270; s896Tg; vu157Tg; vu271Tg
Anatomical Terms:	lens ocular blood vessel blood vessel endothelium retina
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lmo2^vu270/vu270; s896Tg; vu157Tg; vu271Tg
Observed In:	embryonic retina morphogenesis in camera-type eye ocular blood vessel optic fissure retinal blood vessel morphogenesis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 369(2), Weiss, O., Kaufman, R., Michaeli, N., and Inbal, A., Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos, 191-198, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.