FIGURE

Fig. 3

ID

ZDB-FIG-121026-12

Publication

Hsu et al., 2012 - Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm

Other Figures

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Fig. 3

Knockdown of p120 catenin δ1 with the splice-site morpholino led to narrow, extended somites and knobby notochord protrusions, which were rescued by co-injection of Xenopus p120 catenin mRNA (Xp120 catenin mRNA). A: Micrographs of dissected sibling embryos in dorsal view, anterior to the top right, analyzed with in situ hybridization using a myoD probe at the 9- to 10-somite stage. Embryos were injected as indicated in the panels with buffer, δ1 splice-MO (Sp-MO) and/or Xenopus p120 catenin δ1 mRNA (Xp120 mRNA). Scale bars = 100 μm. B: Summary of the average width of the second-to-last somite of in situ hybridized embryos using a myoD probe at the 5- to 13-somite stages. Embryos were injected as in A. C: Summary of the average width-to-length ratio of the second-to-last somite of embryos from 4-somites to 13-somites. Error bars in B and C represent s.e.m. The number of 2 to 35 embryos is marked on the bars.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-ctnnd1
Knockdown Reagent:	MO3-ctnnd1
Observed In:	notochord somite somitogenesis
Stage Range:	5-9 somites to 10-13 somites

Phenotype Detail

Acknowledgments

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