Fig. 7
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- ZDB-FIG-120905-29
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- Filippi et al., 2012 - Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development
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Patterning defects in the prethalamus of arx morphants. Embryos were analyzed by WISH at 30 (A1–D2, K1–L2) or 48 (E1–J2) hpf. The prethalamic expression domains of pax6a (A1–B2, arrows) and lhx1a (C1–D2, arrows) were significantly reduced in arx morphant embryos (B1, B2, D1, D2) compared to controls (A1, A2, C1, C2), whereas an increase in nkx2.2a (E1–F2) expression could be observed at 48 hpf in the prethalamus of arx morphants (F1, F2, arrowhead) compared to controls (E1, E2). olig2 (G1-H2) expression was not perturbed by Arx knockdown at 48 hpf. A specific reduction of gad1/2 (I1–J2) and ascl1a (K1–L2) expression was observed in the prethalamus of the morphants at 48 and 30 hpf, respectively. Abbreviations: HB, hindbrain; Hyp, hypothalamus; PTh, prethalamus; T, tectum, Th, Thalamus; TC, telencephalon. A1-L1 are lateral views; A2-L2 are dorsal views. Anterior is to the left. Scale bars: 100 μm. |
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| Stage Range: | Prim-15 to Long-pec |
Reprinted from Developmental Biology, 369(1), Filippi, A., Jainok, C., and Driever, W., Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development, 133-149, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.