FIGURE

Fig. 4

ID

ZDB-FIG-120724-20

Publication

Flowers et al., 2012 - A zebrafish Notum homolog specifically blocks the Wnt/beta-catenin signaling pathway

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Fig. 4

Notum 1a is required for proper neural tube patterning. (A,B) Compared with uninjected controls at 24 hpf (A), notum1a expression is expanded in the neural tubes of Notum 1a-depleted embryos (P=7.8 × 10^–9) (B). (C,D) Similarly, compared with uninjected embryos at 24 hpf (C), msxc is expanded in notum1a MO-injected embryos (P=2.0 × 10^–4) (D). (E,F) msxc expression is lost in the dorsal neural tube of heat-shocked Tg(hs:notum1a) embryos at 24 hpf (F). Note the normal expression of ntl in the notochord. (G-J) Loss of notum1a leads to ectopic dkk1 expression in the neural tube. Although dkk1 is not observed in the neural tube of uninjected embryos at 24 hpf (G), it was faintly (I) or intensely (H) expressed within the neural tube in the majority of notum1a MO-injected embryos (J).

Expression Data

Genes:	dkk1b msx3 notum1a
Fish:	AB/TU nu20Tg/nu20Tg (AB/TU) AB/TU + MO2-notum1a
Condition:	heat shock
Knockdown Reagent:	MO2-notum1a
Anatomical Terms:	epidermis neural tube notochord posterior neural tube
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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