FIGURE

Fig. 5

ID

ZDB-FIG-120717-35

Publication

Oehlers et al., 2012 - Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis

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Fig. 5

Retinoic acid suppresses the DSS-induced mucosecretory phenotype. (A) Dose-response curve of the percentage of DSS-exposed larvae positive for the mucosecretory phenotype after the administration of a range of doses of RA (n≥20 per group; two biological replicates). (B) Proportion of DSS-exposed larvae positive or negative for the mucosecretory phenotype at 6 dpf after administration of RA at the day indicated. Fisher’s exact test P-values vs untreated controls: 3 dpf<0.0001, 4 dpf=0.0002, 5 dpf=0.0011; n≥20 per group, two biological replicates. (C) Whole-mount in situ hybridization detection of muc expression in the esophagus in control and RA-treated larvae. Blue arrows indicate the location of the esophagus. (D) Alcian-blue-stained esophageal sections of larvae treated with 1 μM RA and exposed to DSS. Arrows indicate the pneumatic duct. Scale bar: 50 μm.

Expression Data

Gene:	muc5.1
Fish:	WT
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Term:	esophagus
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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