FIGURE

Fig. 4

ID

ZDB-FIG-120611-15

Publication

Manfroid et al., 2012 - Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration

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Fig. 4

sox9b early hepatopancreatic expression is activated by FGF and BMP and is maintained in the ducts by FGF and Notch. (A, B) sox9b early expression (30 hpf) in the hepatic and ventral pancreatic primordia (HVP) is not activated in compound fgf10; fgf24 mutants (C, D) Similarly, sox9b is not induced in bmp2a morphants. Note that sox9b in the dorsal pancreatic bud (DP) is not affected.

Expression Data

Gene:	sox9b
Fish:	WT WT + MO3-bmp2a fgf10a^tbvbo/tbvbo; fgf24^{t22030/t22030}
Knockdown Reagent:	MO3-bmp2a
Anatomical Terms:	liver primordium posterior side pancreas primordium anterior side
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-bmp2a fgf10a^tbvbo/tbvbo; fgf24^{t22030/t22030}
Knockdown Reagent:	MO3-bmp2a
Observed In:	liver development pancreas development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 366(2), Manfroid, I., Ghaye, A., Naye, F., Detry, N., Palm, S., Pan, L., Ma, T.P., Huang, W., Rovira, M., Martial, J.A., Parsons, M.J., Moens, C.B., Voz, M.L., and Peers, B., Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration, 268-278, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.