FIGURE

Fig. 3

ID

ZDB-FIG-120329-47

Publication

Royo et al., 2012 - Identification and Analysis of Conserved cis-Regulatory Regions of the MEIS1 Gene

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Fig. 3

HCNR sequence analysis suggests novel meis1 upstream regulators.

(A) meis1 transcription, detected by in situ hybridization (upper panel) compared to GFP expression, driven by the HHc2:066650-GFP transgenic line (lower panel) at 12 (left), 24 (middle) and 30 hpf (right). Side views are shown. HHc2:066650 drives GFP expression in the eye primordium, the early hindbrain, the retina, the optic tectum and the olfactory bulb, which are meis1 expression domains. B) The analysis of the potential binding sites predicted by Jaspar highlights the presence of three potential Pax6 sites. Two of these sites contain a high degree of similarity with the consensus. (C) Pax6_Binding_Site1 also mapped to a microisland of ultraconservation when human and zebrafish orthologous regions were aligned.

Expression Data

Genes:	EGFP meis1b
Fish:	AB/TU upo16Tg (TL)
Anatomical Terms:	eye hindbrain hindbrain neural rod immature eye midbrain neural rod
Stage Range:	5-9 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL + MO2-pax6a AB/TL + MO2-pax6b AB/TL + MO2-pax6a + MO2-pax6b
Knockdown Reagents:	MO2-pax6a MO2-pax6b
Observed In:	eye
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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