Gene

meis1b

ID

ZDB-GENE-020122-1

Name

Meis homeobox 1 b

Symbol

meis1b Nomenclature History

Previous Names

meis1.1 (1)
meis1
cb224 (1)
etID37540.13 (1)
id:ibd5078 (1)
wu:fb38b03 (1)
wu:fc02e11 (1)
wu:fd12a02

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in blood vessel development; hemopoiesis; and positive regulation of angiogenesis. Acts upstream of or within several processes, including blood vessel morphogenesis; embryonic organ development; and embryonic retina morphogenesis in camera-type eye. Located in cytosol and nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; immature eye; nervous system; and neural rod. Orthologous to human MEIS1 (Meis homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

39 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb224 (25 images)
eu422 (26 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With meis1b Human Ortholog

No data available

Associated With meis1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR008422	KN homeodomain
Domain	IPR032453	Homeobox protein PKNOX/Meis, N-terminal
Family	IPR050224	Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox protein PKNOX/Meis, N-terminal	Homeodomain	KN homeodomain	Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:Q90XH2 InterPro	388

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	meis1b-201 (1) Ensembl	Ensembl	2,644 nt	Select Tool ZFIN BLAST
mRNA	meis1b-203 (1) Ensembl	Ensembl	1,392 nt	Select Tool ZFIN BLAST
ncRNA	meis1b-002 (1) Ensembl	Ensembl	893 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-meis1	monoclonal	meis1b	IgG	Rabbit	IHC	Abcam plc Epitomics, Inc	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations