FIGURE

Fig. S1

ID

ZDB-FIG-120315-16

Publication

Prendergast et al., 2012 - The metalloproteinase inhibitor Reck is essential for zebrafish DRG development

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Fig. S1

All alleles of sdp exhibit complete DRG loss. (A) sdp^w13/w13 exhibits normal morphology and pigmentation. Scale bar: 500 μm. (B) A high-magnification image of 3 dpf Tg(neurog1:egfp)/sdp^w13/w13 zebrafish immunostained for Elavl1 reveals no DRG neurons. Scale bar: 50 μm. (C) Approximately 25% of 3 dpf embryos from a cross between sdp^w13/+ parents fail to form neurog1+ DRG, indicating that sdp^w13 is a fully penetrant recessive mutation. (D) sdp^w15/w15 exhibits normal pigmentation but acquires a progressively worsening edema around the eyes and heart beginning at 3 dpf. Scale bar: 500 μm. (E) A high-magnification image of 3 dpf Tg(neurog1:egfp)/sdp^w15/w15 zebrafish immunostained for Elavl1 reveals no DRG neurons. Scale bar: 50 μm. (F) Approximately 25% of 3 dpf embryos from a cross between sdp^w15/+ parents fail to form neurog1+ DRG, indicating that sdp^w15 is a fully penetrant recessive mutation. (G) sdp^w14/w14 exhibits normal morphology and pigmentation. Scale bar: 500 μm. (H) A high-magnification image of 3 dpf Tg(neurog1:egfp)/sdp^w14/w14 zebrafish immunostained for Elavl1 reveals no DRG neurons. Scale bar: 50 μm. (I) Approximately 25% of 3 dpf embryos from a cross between sdp^w14/+ parents fail to form neurog1+ DRG, indicating that sdp^w14 is a fully penetrant recessive mutation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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