FIGURE

Fig. 4

ID

ZDB-FIG-120131-34

Publication

Wang et al., 2011 - Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population

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Fig. 4

Bmp signaling is expanded in mob;mos embryos. (A–H) bmp2b (A–D) and bmp4 (E–H) expression domains (blue) are expanded in mob and mos embryos and further enlarged in mob;mos embryos at 8 hpf. Embryos are oriented according to the position of the prechordal plate marker hgg1 (red). (I–P) The expression domain of chordin is reduced in mob and mos embryos and further diminished in mob;mos embryos. Lateral views I–L; Vegetal views M–P. Arrowheads point to the limits of the signal-positive chordin domain in vegetal view, dorsal side to the right (M–P). (Q–X) The phospho-Smad1/5/8-positive (P-Smad) domain representing active Bmp signaling is increased in mob and mos embryos and further expanded in mob;mos embryos. Embryos in Q–T are shown in lateral view dorsal side to the right, and in U–X in vegetal view, dorsal side to the right. Arrowheads (U–X) point to the limits of the P-Smad domain.

Expression Data

Genes:	bmp2b bmp4 chrd ctslb
Antibody:	Ab1-smad
Fish:	WT foxd3^m188/m188 tfap2a^m610/m610 tfap2a^m610/m610; foxd3^m188/m188
Anatomical Terms:	margin dorsal region non neural ectoderm prechordal plate unspecified
Stage:	75%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 360(1), Wang, W.D., Melville, D.B., Montero-Balaguer, M., Hatzopoulos, A.K., and Knapik, E.W., Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population, 173-85, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.