FIGURE

Fig. S1

ID

ZDB-FIG-120126-72

Publication

Nguyen et al., 2012 - An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

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Fig. S1

Advanced liver tumors in induced kras^V12 double transgenic fish.Morphological and histological examinations of liver tumors were carried out in driver-effector fish induced with mifepristone (RU486) for 8 weeks or longer. Representative brightfiled and fluorescent images of liver morphology and histology of induced Driver-effector fish are shown. (A) One sample from 8 weeks of RU486 treatment. Histoplathological analysis revealed that hepatoblastoma (dotted area) which is made up of undifferentiated cells with large nuclei developed in mixed carcinoma in Driver-effector fish after 8 weeks of induction. In addition, these fish also showed invasion of tumor cells into blood vessels. (B) Examples from more than 8 weeks of mifepristone induction. 10% of induced driver-effector fish developed cyst fluid or malignant ascites in HCC. Detached HCC cells were found in the cysts and blood vessels. Black arrows indicated invasive tumor cells. Scale bars, 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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