FIGURE

Fig. 7

ID

ZDB-FIG-111128-85

Publication

Ben et al., 2011 - Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates

Other Figures

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Fig. 7

Disruption of left-right asymmetry in Mta3 and MZta3 mutants. (A-D) Confocal images of embryos stained with anti-acetylated tubulin (red) and DAPI (blue) showing Kupffer’s vesicle in wild-type (A) Mta3 (B,C) and MZta3 (D). Note the variable number and length of motile cilia in Mta3 embryos compared with wild type. (E-I) Examples of liver and exocrine pancreas orientation revealed by in situ hybridization for the liver marker l-fabp and the pancreas marker trypsin. Orientations are categorized into five phenotypes: left liver and right pancreas, typical of wild-type (E), right liver and left pancreas (F), bilateral (G), absent (H), and centralized liver and pancreas (I). (J) Frequency distribution of different phenotypes among wild-type and ta3/ta3 embryos, and Mta3 and MZta3 mutant embryos.

Expression Data

Genes:	fabp1a prss1
Antibody:	Ab1-tuba
Fish:	WT si:ch211-185a18.2^i264/+; si:ch211-185a18.2ⁱ²⁶⁵; si:ch211-185a18.2^i262/+ si:ch211-185a18.2ⁱ²⁶⁵; si:ch211-185a18.2^i262/+
Anatomical Terms:	Kupffer's vesicle motile cilium liver pancreas
Stage Range:	1-4 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	si:ch211-185a18.2^i264/+; si:ch211-185a18.2ⁱ²⁶⁵; si:ch211-185a18.2^i262/+ si:ch211-185a18.2ⁱ²⁶⁵; si:ch211-185a18.2^i262/+
Observed In:	cilium assembly determination of bilateral symmetry exocrine pancreas Kupffer's vesicle motile cilium liver
Stage Range:	1-4 somites to Long-pec

Phenotype Detail

Acknowledgments

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