FIGURE

Fig. 7

ID

ZDB-FIG-111026-19

Publication

Lu et al., 2011 - Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos

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Fig. 7

Ultrastructural changes of mitochondria and myofibrils in the heart of tbx5-knockdown and wild-type (WT) embryos at 48 h post-fertilization (hpf) under TEM. A: Small mitochondria and well-formed desmosomes can be observed in WT embryos. B: Multiple swollen mitochondria can be observed within myocytes of tbx5 knockdown embryos. C: Well-organized myofibrils with a M line and Z disc can be observed in normal embryos. D: Disarrayed myofibrils appeared in tbx5 knockdown embryos while the M line and Z disc were unrecognizable. E-F: Both the size (E) and number (F) of mitochondria had significantly increased in tbx5 knockdown embryos. Data are presented as the mean ± S.D. An asterisk indicates a significant difference (p < 0.05). mf, myofibril; mt, mitochondria; D, desmosome; ML, M-line; Z, Z-disc; white arrow, disarrayed myofibrils; MO, tbx5 knockdown embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-tbx5a
Knockdown Reagent:	MO1-tbx5a
Observed In:	cardiac muscle cell bicellular tight junction cardiac muscle cell mitochondrion myocardium myocardium myofibril
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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