FIGURE

Fig. 1

ID

ZDB-FIG-111025-9

Publication

Perlin et al., 2011 - Neuronal Neuregulin 1 type III directs Schwann cell migration

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Fig. 1

Neuregulin 1 is required for Schwann cell migration. (A-D2) nrg1 (A,B,B2) and nrg1 type III (C,D,D2) mRNA expression at 33 hpf, shown in dorsal (A,C) and lateral (B,D) views. (B2,D2) Higher magnification of the boxed regions in B,D. Arrowheads mark the PLLg and asterisks mark motoneurons. (E,F) Lateral views of control-injected (E) and nrg1 morpholino-injected (F) zebrafish embryos at 29 hpf. (G-H2) Lateral views of control-injected (G,G2) and morphant (H,H2) embryos carrying the Foxd3:GFP transgene (green) and stained with anti-acetylated tubulin (acTub, red) at 29 hpf. Schwann cells are marked by arrowheads and stellate-shaped pigment cells by asterisks. In lateral views, anterior is to the left and dorsal is up. In dorsal views, anterior is to the left. ALLg, anterior lateral line ganglion; PLLg, posterior lateral line ganglion. Scale bar: 50 μm.

Expression Data

Genes:	GFP nrg1
Antibody:	Ab1-tuba
Fish:	WT zf15Tg zf15Tg + MO3-nrg1
Knockdown Reagent:	MO3-nrg1
Anatomical Terms:	anterior lateral line ganglion neuron immature Schwann cell pigment cell posterior lateral line ganglion neuron posterior lateral line nerve axon spinal cord motor neuron
Stage Range:	Prim-5 to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf15Tg + MO3-nrg1
Knockdown Reagent:	MO3-nrg1
Observed In:	myelinating Schwann cell peripheral nervous system myelin formation posterior lateral line nerve
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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