Gene
nrg1
- ID
- ZDB-GENE-050302-113
- Name
- neuregulin 1
- Symbol
- nrg1 Nomenclature History
- Previous Names
-
- wu:fm70e01
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have signaling receptor binding activity. Involved in several processes, including fin regeneration; nervous system development; and ventricular trabecula myocardium morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; dementia; middle cerebral artery infarction; myocardial infarction; and psychotic disorder (multiple). Is expressed in gut; heart; nervous system; and somite. Orthologous to human NRG1 (neuregulin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| schizophrenia 6 | Alliance | {?Schizophrenia, susceptibility to} | 603013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002154 | Neuregulin, C-terminal |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR040180 | Neuregulin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neuregulin | Neuregulin, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QKS2
|
417 | |||||||||
|
UniProtKB:A0A8M3B1W6
|
724 | |||||||||
|
UniProtKB:A0A0R4IBM0
|
730 | |||||||||
|
UniProtKB:A0A1B4Z255
|
604 | |||||||||
|
UniProtKB:A0A0R4IDP7
|
725 | |||||||||
|
UniProtKB:A0A8M3B1T9
|
729 | |||||||||
|
UniProtKB:B3DK99
|
599 | |||||||||
|
UniProtKB:A0A8M6Z0Q7
|
412 | |||||||||
|
UniProtKB:A0A0R4IFE6
|
687 | |||||||||
|
UniProtKB:A0A8M9QGQ0
|
404 | |||||||||
|
UniProtKB:A0A8M3B955
|
692 | |||||||||
|
UniProtKB:A0A0R4IPH3
|
722 |
Interactions and Pathways
No data available
Plasmids