FIGURE

Fig. S1

ID

ZDB-FIG-110816-6

Publication

Kabashi et al., 2011 - FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis

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Fig. S1

FUS mutations are unable to rescue the phenotype induced by KD of Fus. A) and B) Motor phenotype was assessed both by time frames obtained from video recordings of the TEER as well as immunohistochemical labeling of the axonal projections of motor neurons to determine the UAL. The analysis demonstrates that two ALS-related mutations, R521C (i) and S57Δ (ii), unlike the R521H mutation, do not induce a significant motor phenotype when compared to WT FUS mRNA expression. Whereas R521C (iii) is unable to rescue the motor phenotype induced by KD of Fus, WT (Figure 2) and the S57Δ mutation are able to rescue the motor phenotype caused by Fus KD in zebrafish embryos. All quantifications of the motor phenotype are given in Figure 2 and Table 1. Scale bar: 40 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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