FIGURE

Fig. 3

ID

ZDB-FIG-110712-43

Publication

Mönnich et al., 2011 - A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle

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Fig. 3

Pectoral fin development is impaired in esco2 morphants.

A, B, E, F, The pectoral fin was shorter and abnormally shaped in esco2 morphants. Fins of wild type (A) and morphant (E) live embryos at 3 dpf (dorsal view). Flat-mounted pectoral fins at 2.5 dpf were smaller and less structured in esco2 morphants (F) compared with wild type (B). C, G, D, H, Alcian Blue staining revealed catch-up growth in pectoral fins at 6 dpf. The fins of esco2 morphants (G) were comparable to wild type (C) in size and overall structure. Closer views of cell structure in pectoral fins at 6 dpf showed that cells in esco2 morphant embryos (H) were smaller and more condensed compared to evenly shaped and similar sized cells in wild type (D), perhaps indicating rapid cell divisions in the morphants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-esco2
Knockdown Reagent:	MO1-esco2
Observed In:	pectoral fin pectoral fin cell
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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