FIGURE

Fig. S6

ID

ZDB-FIG-110621-24

Publication

Machuca-Tzili et al., 2011 - Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy

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Fig. S6

Expression of myoD in wild type and mbnl2 MO-1 knockdown zebrafishembyrosat 10hpf (A-B), 18hpf (C-F) and 24hpf (G-H). Two stripes of myoD expression are observed during the tailbudstage (A, B) and appear similar in wild type and MO-1-treated embryos. At 18hpf somites are distinguishable (C-F) and the pattern of myoD expression appears altered slightly in knockdown embryos compared to wild types with reduced expression in the more anterior somites of the morphants (D). Lateral views of this stage show defined chevron patterning in wild type embryos (E) but in the morphants (F) the somitemorphology is more rounded and flattened. During the late segmentation stage (24hpf) myoD is clearly expressed in the somites of wild-type embryos in a highly defined chevron pattern (G). In the morphants (H), the tail is shortened and the somites have an abnormal disc-like morphology.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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