FIGURE

Fig. 2

ID

ZDB-FIG-110621-20

Publication

Machuca-Tzili et al., 2011 - Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy

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Fig. 2

The severity of the phenotype of mbnl2 morphants varies in a dose-dependent manner. (A) Alignment of the three zebrafish MBNL genes and morpholinos 1 (blue box) and 2 (green box), showing the specificity of both morpholinos for mbnl2. The initiation codon is boxed in red. (B–D) Control embryos (B) compared with mildly (C) and severely (D) affected morphant embryos at 51 hpf. (F,G) Developmental defects in mbnl2 morphants include hypoplastic hypopigmented eyes and brain malformations; the hindbrain ventricle is swollen or enlarged, producing a convex appearance. (I,J) The hearts are hypoplastic and are elongated (I) or dilated (J), showing pericardial oedema, which results in bradycardia and failure. (K–M) The tails are twisted (L) or shortened (M), and the classic somite chevron-shape (K) is replaced by an oval or U shape (L, M). (B,E,H,K) Control embryos. Inset in E shows a normal wild-type eye.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mbnl2
Knockdown Reagent:	MO1-mbnl2
Observed In:	brain eye fourth ventricle heart pericardium post-vent region somite
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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