FIGURE

Fig. 6

ID

ZDB-FIG-110428-7

Publication

Tse et al., 2011 - The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Zebrafish cops6 plays an anti-apoptotic role in early development. TUNEL assay of wild-type embryos and cops6 morphants at different developmental stages. There were no significant differences between (A) control and (B) cops6 morphants at 50-60% epiboly stage. At the 12-14 somite stage, (D) cosp6 morphants showed increased positive staining of apoptotic cells in the trunk region (white asterisk) when compared to (C) control; lateral view. Apoptotic cells (arrows) at the same stage, dorsal view (insert), were found in (D) cops6 morphants, but not in (C) control. Afterwards, at (E,F) prim-5 stage, increased numbers of apoptosis-positive stained cells (arrows) were found only in (F) cops6 morphants. (G,H) At the 12-14 somite stage, the apoptotic dying cells, exhibiting a rounded-up cell body (arrowheads), were found in (H) cops6 morphants. Scale bar: 1250 μm (A,B), 210 μm (C-F) and 150 μm (G,H).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-cops6
Knockdown Reagent:	MO1-cops6
Observed In:	apoptotic process
Stage Range:	10-13 somites to Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Dev. Biol.