FIGURE

Fig. S7

ID

ZDB-FIG-110407-22

Publication

Kim et al., 2011 - Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin

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Fig. S7

Mild ER stress increases TORC1 signaling in tsc2^vθ²⁴²^/^b>⁺ zebrafish. Wild-type and tsc2^vu242/+ siblings were treated with tunicamycin (Tn) (B,C,E,F). Untreated wild-type (A) and tsc2^vu242/+ heterozygous zebrafish at 8 dpf (D) had minimal TORC1 activity. Markedly increased TORC1 signaling was seen with 200 ng/ml of Tn tsc2^vu242/+ heterozygous zebrafish (E) compared to Tn treated wild-type (B). Treatment of both tsc2^vu242/+ heterozygous zebrafish (F) and wild-type (C) zebrafish with 400 ng/ml of Tn led to increased TORC1 signaling evidenced by phospho-S6 (Ser235/236) staining. L, liver. Scale bar equals 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.