FIGURE

Fig. 7

ID

ZDB-FIG-110407-17

Publication

Kim et al., 2011 - Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Adult brain abnormalities after tsc2^vu242/vu242 mutant cell transplantation. (A–L) Coronal sections of adult brain at 1 year of age. (A) Green (GFP) indicates transplanted wild-type cells, blue (DAPI) shows nuclei and red shows phospho-S6 staining. (B) DAPI channel of A. (C–L) Cell clusters were found 1 year after transplantation in wild-type host zebrafish of tsc2^vu242/vu242;Tg(β-actin:mGFP) donor cells. (C,E,G,I,L) Green cells indicate transplanted tsc2^vu242/vu242;Tg(β-actin:mGFP) cells. (D,H,K) DAPI staining showing disruption of gray and white matter in wild-type host brain. (C,G) Distance between the two cortical sections shown is 50 μm. (F,J) Red shows phospho-S6 staining. (D,H) Selected areas surrounded by yellow line indicate a disruption of gray and white matter. (C) Merged image of D–F; (L) merged image of I–K. (M) Schematic of brain structure (rectangle) for I–L. TeO, tectum opticum; HaV, ventral habenular nucleus; AT, anterior thalamic nucleus; VL, ventrolateral thalam. Scale bars: 50 μm (A–H); 200 μm (I–L).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.