FIGURE

Fig. 1

ID

ZDB-FIG-101206-17

Publication

den Hollander et al., 2010 - Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies

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Fig. 1

Phenotype of the zebrafish out of sight mutant. (A - B) Lateral views of wild-type zebrafish (A) and of the out^m233mutant (B) at 36 hpf, 48 hpf (a1 and b1), 72 hpf (a2 and b2) and 96 hpf (a3 and b3). The out^m233mutant is characterized by a severe reduction in eye size. No obvious defects are observed in other organs. (C - D) Transverse plastic sections of wild-type (C) and out^m233mutant (D) retinae at 36 hpf, 4 dpf (c1 and d1) and 5 dpf (c2 and d2). Although the retina and lens are grossly reduced in size in out^m233mutants, their overall architectures appear largely intact. (E - F) An anophthalmic out^m233homozygous mutant at ca. 2 months of age. An enlargement of the head region is shown in (F). (G - H) A wild-type individual (G) and its microphthalmic out^m233sibling (H) at 2.5 months of age. In A, B, and E-H, anterior is to the left

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gdf6a^m233/m233 (AB)
Observed In:	eye lens retina
Stage Range:	Prim-25 to Days 45-89

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Genet.