FIGURE

Fig. S5

ID

ZDB-FIG-101118-54

Publication

Gosse et al., 2009 - An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina

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Fig. S5

Additional analysis of Radar signaling and regulation. (A-G) Dissected eyes following whole-mount in situ hybridizations on 26-somite embryos with the antisense probes indicated. (Scale bars, 50 μm.) (A) WT eyes express tbx5 in the dorsal retina, opposite of the optic fissure. (B) lost-a-fin (laf ) mutants, lacking functional Alk8 receptor, have reduced expression of tbx5. (C) In WT eyes radar expression is restricted to a narrow patch opposite of the optic fissure. (D) In sonic you (syu) mutants, in which Shh is disrupted, radar expression is slightly expanded to the ventral retina. (E-G) bmp2b overexpression mirrors the effects of bmp4 overexpression. hsp70:bmp2b transgenic fish were induced at 12-14 somites to overexpress bmp2b. radar expression is weakly expanded, tbx5 expression is strongly up-regulated, vax2 expression is absent from the retina.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA