FIGURE

Fig. 5

ID

ZDB-FIG-100804-9

Publication

Roman et al., 2002 - Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels

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Fig. 5

Antisense morpholino-modified oligonucleotides directed against acvrl1 phenocopy vbg mutants. Dorsal anterior angiograms of 2.25 dpf wild-type embryos injected at the 1- to 4-cell stage with 22.5 ng of a standard control morpholino (A) or 22.5 ng (C) or 15 ng (D) of a mixture of morpholinos directed against acvrl1. Note the strong resemblance of patent vessel architecture in C to that found in vbg mutants (B). The embryo shown in D is less severely affected but clearly shows dilated vessels and a decrease in the number of patent central arteries. BCA, basal communicating artery; PCS, posterior connecting segment; BA, basilar artery; PHBC, primordial hindbrain channel; CA, central artery. Dorsal views, anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	acvrl1^y6/y6 (AB) WT + MO1-acvrl1 + MO2-acvrl1
Knockdown Reagents:	MO1-acvrl1 MO2-acvrl1
Observed In:	central artery cranial blood vessel
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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