FIGURE

Fig. 6

ID

ZDB-FIG-100707-36

Publication

Rojas-Muñoz et al., 2009 - ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration

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Fig. 6

ErbB2 is expressed upon amputation all along the regenerating caudal fin of adult fish. Before amputation (Uncut) the amount of ErbB2 in the caudal fin is undetectable. However, ErbB2 is strongly accumulated after 1 dpi (Fig. S5) and 3 dpi. Similarly, the degree of protein phosphorylation at Y residues is low before amputation compared to amputated wild-type fins at 1 dpi and 3 dpi. Homozygous adults for hps^t21411 exhibit a similar pattern of ErbB2 expression and Y-phosphorylation compared to wild-type fins, despite the absence of regeneration. Like in larval stages, ErbB2 is present all over the fin, including the plasma membrane of blastema cells (white arrowheads) and the neuromasts. In all cases, the ErbB2 signal often overlaps with the phospho-Y signal.

Expression Data

Gene:	erbb2
Antibodies:	Ab1-erbb2 Ab1-pY
Fish:	AB erbb3b^{t21411/t21411} (AB)
Anatomical Term:	regenerating fin
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 327(1), Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C., ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration, 177-190, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.