FIGURE

Fig. 7

ID

ZDB-FIG-100506-18

Publication

Nguyen et al., 2010 - The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish

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Fig. 7

Development of neural crest cells is dependent upon Leo1 function. (A, B) Dorsal anterior view of dlx2 expression in pharyngeal arch neural crest at the 18S stage. The expression pattern of dlx2 is normal in wild-type (A) and leo1^LA1186 embryos (B). (C–J) Pan-neural crest marker, crestin, at the 12 somite stage (C–F) and 24hpf (G–J). Crestin expression is detected in anterior and trunk neural crest of wild-type embryos (C, E, G, I), but is severely reduced in the region anterior to the otic vesicle of leo1^LA1186 mutants (D, F, H, J). (C, D, G, H) Lateral view. (E, F, I, J) Dorsal anterior view.

Expression Data

Genes:	crestin dlx2a
Fish:	WT leo1^{la1186/la1186}
Anatomical Terms:	neural crest cell pharyngeal arch epithelium
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	leo1^{la1186/la1186}
Observed In:	neural crest cell development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 341(1), Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N., The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish, 167-175, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.