FIGURE

Fig. 1

ID

ZDB-FIG-100506-12

Publication

Nguyen et al., 2010 - The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish

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Fig. 1

Loss of Leo1 function results in cardiac abnormalities and absence of pigmentation (A, B, C) Lateral view of a two-day-old wild-type embryo (A), a leo1^LA1186 mutant (B) and a leo1^LA1186 mutant injected with wild-type leo1 mRNA (C). (D, E, F, G) Dorsal view. Expression patterns of cardiac markers, nkx2.5 (D, E) and cmlc2 (F, G), are indistinguishable between wild-type siblings (D, F) and leo1^LA1186 mutants (E, G) at the 10 somite stage and 24 h post fertilization, respectively. (H, I) Histological sections. In contrast to wild-type hearts (H), the cardiac chambers of leo1^LA1186 mutants are collapsed by 2 dpf (I). o, outflow tract; v, ventricle; a, atrium; sv, sinus venosus.

Expression Data

Genes:	myl7 nkx2.5
Fish:	WT leo1^{la1186/la1186}
Anatomical Terms:	heart primordium heart tube
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	leo1^{la1186/la1186}
Observed In:	bulbus arteriosus cardiac ventricle melanocyte sinus venosus xanthophore
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 341(1), Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N., The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish, 167-175, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.