FIGURE

Fig. 6

ID

ZDB-FIG-100223-28

Publication

Camarata et al., 2010 - Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation

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Fig. 6

Pdlim7 is required for AV boundary specification. (A–F) In situ hybridization of tbx5 at 24 hpf (A-C) and 48 hpf (D–F) in wild-type (A, D), MO1 (B, E), and MO2 (C, F) injected embryos. (G-O) Expression at 48 hpf of versican (G-I), bmp4 (J-L), and notch1b (M-O). (P-R) Expression of AV boundary markers in hst homozygous embryos.

Expression Data

Genes:	bmp4 myl7 notch1b tbx5a vcana
Fish:	WT tbx5a^m21/m21 WT + MO3-pdlim7 WT + MO4-pdlim7 tbx5a^m21/+
Knockdown Reagents:	MO3-pdlim7 MO4-pdlim7
Anatomical Terms:	atrioventricular canal atrioventricular canal endocardium eye heart heart tube
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx5a^m21/m21 WT + MO3-pdlim7 WT + MO4-pdlim7
Knockdown Reagents:	MO3-pdlim7 MO4-pdlim7
Observed In:	atrial ventricular junction remodeling atrioventricular canal
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 337(2), Camarata, T., Krcmery, J., Snyder, D., Park, S., Topczewski, J., and Simon, H.G., Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation, 233-245, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.