FIGURE

Fig. 2

ID

ZDB-FIG-100114-11

Publication

Dovey et al., 2009 - Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

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Fig. 2

NRAS^Q61K cooperates with p53 loss in melanoma formation. (A) Tumor-bearing fish were identified by visual inspection and checked for fluorescence. The box around the tumor is shown in (B) under fluorescent light. (C, D) Tumor-free survival curves are shown. Three hundred and forty-two NRAS1 sibling and 167 NRAS2 sibling fish were inspected weekly for these studies. The location of tumors in NRAS1;p53^-/- and NRAS2;p53^-/- fish is shown in (E) and (F), respectively. (G, H) Loss of heterozygosity of the wild-type p53 allele is shown. One hundred percentage of NRAS1;p53^+/- fish and 57% of NRAS2;p53^+/- fish lose the wild-type copy of p53.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/+; zf170Tg tp53^zdf1/+; zf171Tg tp53^zdf1/zdf1; zf170Tg tp53^zdf1/zdf1; zf171Tg
Observed In:	melanocyte pigmentation
Stage:	Adult

Phenotype Detail

Acknowledgments

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