ZFIN Image: Dovey et al., 2009, Fig. 2

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Figure Caption

Fig. 2 NRAS^Q61K cooperates with p53 loss in melanoma formation. (A) Tumor-bearing fish were identified by visual inspection and checked for fluorescence. The box around the tumor is shown in (B) under fluorescent light. (C, D) Tumor-free survival curves are shown. Three hundred and forty-two NRAS1 sibling and 167 NRAS2 sibling fish were inspected weekly for these studies. The location of tumors in NRAS1;p53^-/- and NRAS2;p53^-/- fish is shown in (E) and (F), respectively. (G, H) Loss of heterozygosity of the wild-type p53 allele is shown. One hundred percentage of NRAS1;p53^+/- fish and 57% of NRAS2;p53^+/- fish lose the wild-type copy of p53.

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Acknowledgments

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