FIGURE

Fig. 2

ID

ZDB-FIG-091026-3

Publication

Hong et al., 2009 - FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1

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Fig. 2

Ier2 and Fibp1 are required for convergent extension. Control (A and B) and ier2 morphant (C and D). Lateral (A and C) and dorsal (B and D) views at the 5-somite stage. Brackets in A and C show the distance between head and tail, and arrowheads in B and D show the width of the somites. (E–L) Two-color in situ hybridization with marker genes at the 3-somite stage. Dorsal views of anterior (E–H) and posterior (I–L) region. (E and I) Drawings of a normal embryo indicating the patterns of the markers used, ctsl1b (red), dlx3b (blue), ntl (blue), and pcdh8 (red). (F and J) Control MO-injected embryo. (G and K) ier2 MO-injected embryo. (H and L) fibp1 MO-injected embryo. In the experimental embryos, notochord and somites are wider and extension along the A/P axis is reduced.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ier2a
Knockdown Reagent:	MO1-ier2a
Observed In:	convergent extension notochord somite whole organism
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA