FIGURE

Fig. 3

ID

ZDB-FIG-090831-38

Publication

French et al., 2009 - Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development

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Fig. 3

Analysis of Bmp expression in the retina. gdf6a expression is first detected at the 3 somite stage adjacent to the developing eye field (A), while bmp4 expression is limited to the polster (B). The expression domain of gdf6a is reduced by 6 somites, but still located adjacent to the eyecups (C). bmp4 expression is still confined to the polster at 6 somites (D). By 10 somites, both gdf6a and bmp4 expression are found within the presumptive dorsal retina (E, F). Morpholino inhibition of Gdf6a reduces the expression of gdf6a and bmp4 (I, J,). By 28 hpf, both gdf6a and bmp4 are confined to the dorsal retina (G, H), and are down-regulated in gdf6a morphants at 28 hpf (K, L).

Expression Data

Genes:	bmp4 gdf6a
Fish:	WT WT + MO1-gdf6a + MO4-tp53
Knockdown Reagents:	MO1-gdf6a MO4-tp53
Anatomical Terms:	head optic cup dorsal region optic vesicle polster
Stage Range:	1-4 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 333(1), French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J., Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development, 37-47, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.