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Fig. 2

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ZDB-FIG-090716-8

Publication

Paridaen et al., 2009 - Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival

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Fig. 2

Loss of Apc function leads to mispatterning of the forebrain. Lateral view, anterior to the left. (A–D) As compared to wild-type embryos (A), emx3 expression expands into ventral telencephalon (asterisk) and posterior ventral hypothalamus (arrow) in apc mutants at 36 hpf (B). At 42 hpf (C, D), emx3 further expands into anterior dorsal hypothalamus (dashed line and arrowhead in panel D) and the telencephalic–diencephalic boundary. (E–H) wnt8b (E, F) and pax6.1 (G, H) expand rostrally into the telencephalon and caudally into the thalamus of apc mutants (F, H) at 48 hpf. Dashed line in panels A–H indicates the telencephalic–diencephalic boundary. An additional line in panels G, H indicates the ventral/dorsal midbrain boundary. (I, J) In apc mutants, shh expression is absent from the ZLI and anterior dorsal hypothalamus at 48 hpf (J). Dashed line indicates the ZLI. ad, anterior dorsal hypothalamus; di, diencephalon, e, epithalamus; fp, floorplate; pv, posterior ventral hypothalamus; t, thalamus; ZLI, zona limitans intrathalamica. Scale bar 125 μm.

Expression Data

Genes:	emx3 pax6a shha wnt8b
Fish:	WT apc^zf134/zf134
Anatomical Terms:	diencephalon epithalamus floor plate hypothalamus hypothalamus antero-dorsal region hypothalamus postero-ventral region pretectum telencephalon telencephalon diencephalon boundary thalamus ventral telencephalon zona limitans intrathalamica
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^zf134/zf134
Observed In:	forebrain forebrain anterior/posterior pattern specification forebrain dorsal/ventral pattern formation negative regulation of canonical Wnt signaling pathway zona limitans intrathalamica
Stage Range:	Prim-25 to Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 331(2), Paridaen, J.T., Danesin, C., Elas, A.T., van de Water, S., Houart, C., and Zivkovic, D., Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival, 101-112, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.