FIGURE

Fig. 3

ID

ZDB-FIG-090512-3

Publication

Covassin et al., 2009 - A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development

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Fig. 3

Defects in circulatory function in kdrl mutants. (A–G) Transmitted light images of wild type and kdrl mutant zebrafish embryos at 55 h post fertilization. Lateral views, anterior to the left, dorsal is up. (A) Wild type sibling embryo. Scale bar is 250 μM. (B) kdrl^um6 mutant embryo displaying cardiac edema (white arrow). (C) Eye (indicated) and forebrain region of wild type sibling embryo. Scale bar is 50 μM. (D) Cranial hemorrhage (white arrows) in a heterozygous carrier of the kdrl^um6 allele. (E) kdrl^um6 heterozygous embryo. (F) kdrl^um19 mutant embryo. (G) Eye and forebrain region of a kdrl^um19 mutant embryo. A cranial hemorrhage is indicated by the white arrow. (H) Quantification of circulatory defects in clutches of embryos derived from incrosses of um6, um19, and y17 heterozygous carriers; circ — circulation, shunt — abnormal circulatory connection between dorsal aorta and posterior cardinal vein, hem — cranial hemorrhage.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kdrl^um6/+; y1Tg kdrl^um6/um6; y1Tg kdrl^um19/um19; y1Tg
Observed In:	blood circulation cranial vasculature dorsal aorta intersegmental artery pericardium posterior cardinal vein
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 329(2), Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M., and Lawson, N.D., A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development, 212-226, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.