FIGURE

Fig. 2

ID

ZDB-FIG-081218-12

Publication

Wang et al., 2008 - Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development

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Fig. 2

The posterior-to-anterior (PA) propagation of pitx2 and lft1 depends on spaw function. A,B: In wild-type (WT; A) pitx2 is expressed in lateral plate mesoderm (LPM; black arrow) and in Rohon-Beard cells (black arrowhead). In spaw morphants (B), pitx2 is not expressed in LPM but is expressed in Rohon-Beard cells (black arrowhead). Embryos were at 18 somite stage (SS); anterior to left. C,D: Spaw expression is normal in WT (C) and spaw morphants (D) in the peri-Kupffer's vesicle (KV) bilateral domains (green arrow). In contrast, left-sided LPM spaw expression (green arrowhead) and lft1 midline expression (blue arrow) seen in WT (C) is absent in spaw morphants (D). Embryos were 16 SS; anterior to the top.

Expression Data

Genes:	lft1 pitx2 spaw
Fish:	WT WT + MO1-spaw
Knockdown Reagent:	MO1-spaw
Anatomical Terms:	lateral plate mesoderm notochord Rohon-Beard neuron tail bud
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-spaw
Knockdown Reagent:	MO1-spaw
Observed In:	lateral plate mesoderm notochord
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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